Abstract
A series of 5-(2- or 3-thienyl)tryptamine derivatives (9) has been synthesized and shown to be potent and selective 5-HT1D versus 5-HT1B receptor agonists and, therefore, potential treatments for migraine.
MeSH terms
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Cloning, Molecular
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Humans
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Indicators and Reagents
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Migraine Disorders / drug therapy*
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Receptor, Serotonin, 5-HT1B
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Receptor, Serotonin, 5-HT1D
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Receptors, Serotonin / drug effects*
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Serotonin Antagonists / chemical synthesis*
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Serotonin Antagonists / pharmacology
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Structure-Activity Relationship
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Tryptamines / chemical synthesis*
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Tryptamines / pharmacology
Substances
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HTR1B protein, human
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Indicators and Reagents
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Receptor, Serotonin, 5-HT1B
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Receptor, Serotonin, 5-HT1D
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Receptors, Serotonin
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Serotonin Antagonists
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Tryptamines